5-HTP occurs naturally in two places - the human body and the seeds of the Griffonia Simplicifolia, a West African medicinal plant. 5-HTP is an amino acid produced by the body from the essential amino acid L-tryptophan (LT), which is found in dietary proteins. It is known for its ability to increase the producation of seretonin. Since eating foods that contain L-tryptophan won't significantly increase 5-HTP levels, it is processed from the seeds of the Griffonia Simplicifolia and marketed as a dietary supplement.

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5-HTP mood enhancer is the precursor to serotonin. It improves mood, anxiety and is beneficial in weight loss. In the tissue of the intestine, it acts as a stimulant to make the smooth muscle contract. In the brain, seretonin acts as a neurotransmitter that aids in the transmission of nerve impulses between synapses. These functions make serotonin very important to all of the body's system.

GABA is a non-essential amino acid produced in the brain. It acts as a neurotransmitter, a chemical that fosters communication between nerve cells, and helps to keep stress-related nerve impulses at bay. GABA is referred to as the "brain's natural calming agent".

GABA supplements appear to promote relaxation and sleep. They may also have a role to play in preventing seizures and allaying chronic pain.

St. John's Wort is a common shrub-like perennial, bears bright yellow flowers containing numerous therapeutic substances when dried. Extract of Hypericum perforatum L. (St John's wort) has recently been embraced in North America for its use as a treatment for depression and conditions associated with it.

Although studied for decades, researchers still don't know exactly how the herb works. A pigment called hypericin has long been identified as the key medicinal ingredient that reacts with specific chemicals in the brain to temper emotional discomfort, lift depression, and calm the nerves. St. John's wort appears to boost levels of the brain chemical serotonin, which affects the emotions. Natural extracts from St. John's Wort have shown to relax and soothe the psyche with minimal side effects.

SAMe is a naturally occuring compound in the body, essential to healthy activity in all human cells and supports the production of healthy joint tissue. It is said to be an effective treatment for depression, arthritis, and liver disease, and may postpone the onset of osteoarthritis in older people or athletes.

Supplementation with SAM-e increases levels of serotonin, dopamine and phosphatides, and improves serotonin and dopamine receptor site binding. It is known to be essential to at least 35 biochemical processes, including maintaining the structure of cell membranes and manufacturing substances vital to transmitting nerve impulses and influencing emotions and moods.